Scalable Nanodiamond Microfilm Platforms for Sustained Molecular Delivery
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| Audience/Grade: | High School Junior -Professional Development 11-Professional Development |
| Discipline(s): |
Manufacturing Engineering Materials Engineering Mechanical Engineering Nanotechnology |
| Special Topic(s): | |
| Learning Resource Type: |
Reference - Article/Document |
| Media Type: |
Audio |
| Author(s): |
SINAM Organization |
| Description: | Scalable nanodiamond (ND)-embedded platforms were developed by fabricating a microfilm device by coupling a parylene-based biostable polymer complex with ND-Doxorubicin chemotherapeutic clusters. This served as a versatile approach towards the integration of nanomanufacturing with healthcare in that virtually any drug could be loaded into this system. NDs possess several advantageous properties as drug carriers including the fact that they can be batch functionalized and purified, possesses demonstrated cellular, tissue, and organism level biocompatibility/lack of toxicity, have high loading capacities, and can be suspended in water for both particle-based delivery and easy integration into polymeric devices. The microfilm device that was demonstrated by this work was capable of eliminating the ‘burst’ release effect while maintaining consistent release profiles for at least one month. Also, the chemical vapor deposition of the microfilms coupled with facile ND-drug deposition enabled device architectures (e.g. thickness, shape, flexibility) to be easily controlled. Furthermore, this fabrication strategy allows for multi-drug and sequential drug release to further promote enhancements in therapeutic efficacy. |
| Rating: | No Rating |
| Related Resources | |
| Keywords: | Scalable Nanodiamond Microfilm Patterns Sustained Molecular Delivery SINAM nanomanufacturing |
| Version Info | |
| Publication Date: | June 2008 |
| Platform/Format: |
WWW |
| Cost: |
Free |
| Download URL: | http://sinam.org/pdf/Northwestern_NSEC_0751621_nanodiamond.pdf |
| Metadata: |
IEEE LOM Record |
| Collection: |
SINAM
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